Bash

• GetSSL (bash, also automates certs on remote hosts via ssh)
• acme.sh (Compatible to bash, dash and sh)
• dehydrated (Compatible to bash and zsh)
• ght-acme.sh (batch update of http-01 and dns-01 challenges is available)
• bacme (simple yet complete scripting of certificate generation)
• wdfcert.sh (Only supports DNS-01 challenges and ECDSA-384 bit keys for both accounts and certificates, native Joker DNS support including wildcard plus root domain support for single-TXT-record DNS providers)

C

• OpenBSD acme-client
• uacme
• acme-client-portable
• Apache httpd Support via the module mod_md.
• mod_md Separate, more frequent releases of the Apache module.
• CycloneACME (client implementation of ACME dedicated to microcontrollers)

C++

• acme-lw
• esp32-acme-client allows IoT devices to get certificates

Clojure

• certificaat

Configuration management tools

• Ansible acme_certificate module
• Terraform ACME Provider
• Ansible collection: acme (ACME V2 integration with acme_certificate module. Supports multiple providers for challenges)

D

• acme-lw-d

Domino

• CertMatica (ACME certificate installation and renewals for HCL Domino™ servers)
• HCL Domino (Full ACME V2 flow integration for HCL Domino™ servers)

Docker

• Crypt::LE
• acme.sh
• letsproxy

Go

• Caddy
• Lego
• acmetool
• Lets-proxy2 (Reverse proxy to handle https/tls)
• autocert
• Traefik
• ACMEz
• Step CLI
• J8a (Reverse proxy for JSON APIs with auto-renewing TLS 1.3)
• certmanager (Supports certificate sharing across instances/pods and split-horizon DNS with acme-proxy)

HAProxy

• HAProxy client

Java

• PJAC
• ManageEngine Key Manager Plus

Kubernetes

• cert-manager
• KCert

Lua

• Mako Server's ACME Plugin The plugin’s main objective is to provide certificates for servers on private networks.

Microsoft Azure

• Azure WebApp SSL Manager (Serverless, Compatible with any App Service, requires Azure DNS)
• App Service Acmebot (Compatible to Azure Web Apps / Functions / Web App for Containers)
• Key Vault Acmebot (Work with Azure Key Vault Certificates)
• Az-Acme (The simplest ACME Issuer for Azure Key Vault)

nginx

• njs-acme JavaScript library compatible with the ’ngx_http_js_module’ runtime (NJS), allows for the automatic issue of TLS/SSL certificates for NGINX without restarts
• lua-resty-auto-ssl
• Nginx ACME
• docker-openresty An Openresty image with auto ssl, using acme.sh
• docker-nginx An Nginx image with auto ssl, using acme.sh
• lua-resty-acme

Node.js

• Greenlock for Express.js
• acme-http-01-azure-key-vault-middleware (Express middleware for storing certificates securely on Azure Key Vault)

OpenShift

• openshift-acme
• certman-operator

Perl

• acme (Simple json config, autogen keys, issue cert, refresh cert, apache/nginx integration)
• Crypt::LE

PHP

• kelunik/acme-client
• AcmePHP
• FreeSSL.tech Auto
• Yet another ACME client
• itr-acme-client PHP library
• Acme PHP
• RW ACME client

Python

• ACME Tiny
• simp_le
• acmebot
• sewer
• acme-dns-tiny (Python 3)
• Automatoes ACME V2 ManuaLE replacement with new features
• acertmgr
• acme-cert-tool
• serverPKI PKI for internet server infrastructure, supporting distribution of certs, FreeBSD jails, DNS DANE support
• acmetk acmetk is an ACMEv2 proxy to centralize certificate requests and challenges within an organisation and direct them using a single account to Let’s Encrypt or other ACMEv2 capable CA’s.

Ruby

• unixcharles/acme-client
• acme-distributed
• Combine-acme: Generate and upload crt to CloudFlare(enterprise) and GCP.

Rust

• ACMEd
• acme-redirect

Windows / IIS

• Crypt::LE (previously ZeroSSL project)
• win-acme (.NET)
• Posh-ACME (PowerShell)
• Certes
• ACME-PS (PowerShell)
• kelunik/acme-client (PHP)
• Certify The Web (Windows)
• WinCertes Windows client
• GetCert2 (simple GUI - .Net, C#, WPF, WCF)
• TekCERT (GUI, CLI)

Server

• Certera (Crossplatform PKI to centrally manage keys and certificates)

ספריות

4D

• acme component ACME Client v2 for 4D v18+

C++

• acme-lw
• esp32-acme-client allows IoT devices to get certificates

D

• acme-lw-d

Delphi

• DelphiACME (Embarcadero Delphi)

Go

• Lego
• acmetool
• eggsampler/acme
• ACMEz
• certmanager (Supports certificate sharing across instances/pods and split-horizon DNS with acme-proxy)

Java

• ACME4J

.NET

• Certes (.NET Standard)
• PKISharp/ACMESharpCore (.NET Standard)

Node.js

• Greenlock for node.js
• publishlab/node-acme-client

Perl

• acme (Simple json config, autogen keys, issue cert, refresh cert, apache/nginx integration)
• Crypt::LE
• Net::ACME2
• wdfcert.sh (Only supports DNS-01 challenges and ECDSA-384 bit keys for both accounts and certificates, native Joker DNS support including wildcard plus root domain support for single-TXT-record DNS providers)

PHP

• kelunik/acme
• ACMECert PHP library
• LEClient PHP library
• le-acme2-php library
• stonemax/acme2 PHP client
• Acme PHP Library

Python

• המודול acme ל־Python הוא חלק מ־Certbot, אך נעשה בו שימוש גם בלקוחות אחרים והוא גם זמין כחבילה עצמאית דרך PyPI,‏ Debian,‏ Ubuntu,‏ Fedora ומגוון הפצות נוספות.
• txacme (Twisted client for Python 2 / 3)

Ruby

• unixcharles/acme-client

Rust

• instant-acme is an async, pure-Rust ACME (RFC 8555) client which relies on Tokio
• rustls-acme provides TLS certificate management and serving using rustls
• tokio-rustls-acme is an easy-to-use, async ACME client library for rustls

מיזמים שיודעים להשתלב מול Let's Encrypt

• Aegir
• Aerys
• Apache HTTP Server
• ApisCP
• Caddy
• CentminMod LEMP Stack
• Certhub
• Cloudfleet
• Cloudron
• cPanel
• Froxlor Server Management Panel
• Gitlab
• ISPConfig
• LiveConfig Hosting Control Panel
• Mail-in-a-Box
• Own-Mailbox
• pfSense
• Plesk Web Hosting Control Panel
• Ponzu CMS
• ruxy
• SWAG - Secure Web Application Gateway
• Synchronet BBS System
• Vesta Control Panel
• Virtualmin Web Hosting Control Panel
• WildFly Application Server
• Zappa
• Proxmox Virtual Environment